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Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and antiiflammatory agents

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National Technical University of Athens   

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Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and antiiflammatory agents (EN)
Koufaki, M (EN)
Melagraki, G (EN)
Prousis, KC (EN)
Kontogiorgis, C (EN)
Detsi, A (EN)
Hadjipavlou-Litina, DJ (EN)
Igglessi-Markopoulou, O (EN)
Athanasellis, G (EN)
Afantitis, A (EN)
Bouloumbasi, D (EN)
journalArticle (EN)
2014-03-01T01:56:28Z
2007 (EN)
A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity. (EN)
Chemistry, Medicinal (EN)
ANTIINFLAMMATORY ACTIVITY (EN)
LIPID-PEROXIDATION (EN)
ACTIVE METHYLENE-COMPOUNDS (EN)
5-LIPOXYGENASE INHIBITORS (EN)
REPERFUSION ARRHYTHMIAS (EN)
BIOLOGICAL EVALUATION (EN)
PPAR-GAMMA AGONISTS (EN)
DUAL INHIBITORS (EN)
STEP SYNTHESIS (EN)
ACETIC-ACID (EN)
JOURNAL OF MEDICINAL CHEMISTRY (EN)
English
AMER CHEMICAL SOC (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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