Prevalence and longterm course of primary biliary cirrhosis in primary Sjogrens syndrome

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



Prevalence and longterm course of primary biliary cirrhosis in primary Sjogrens syndrome (EN)

Fragoulis, GE (EN)
Moutsopoulos, HM (EN)
Barbatis, C (EN)
Hatzis, GS (EN)
Karatzaferis, A (EN)
Delladetsima, I (EN)

journalArticle (EN)

2014-03-01T01:57:35Z
2008 (EN)


Objective. To study the prevalence of primary biliary cirrhosis (PBC) and its progression in patients with primary Sjogren's syndrome (SS). Methods. We investigated 410 patients with primary SS, without history of liver disease. For the presence of PBC based oil it retrospective review of clinical, biochemical, immunologic, and histologic data. Results. Thirty-six (8.8%) patients had cholestatic liver biochemistry. Of them, 21 (5.1%) had positive antimitochondrial autoantibodies (AMA) detected by indirect immunofluorescence, while 15 were AMA-negative. Tell of the 21 ANIA-positive patients and 7 of the 15 AMA-negative patients were further investigated) with liver biopsy. the result of which was compatible with PBC in all but one (AMA-negative) Patient. Overall, 27 (6.6%) patients had definite (n = 10). probable (it = 11). or AMA-negative (n = 6) PBC. Pathologically, most PBC lesions were stage 1. Five patients had a second liver biopsy. with no significant histological deterioration. Conclusion. PBC is a rather Uncommon development in Patients with primary SS. The disease appears to be pathologically mild, with a propensity for slow progression. as assessed clinically, biochemically, and histologically. (EN)

Rheumatology (EN)

AUTOANTIBODIES (EN)
EPITHELITIS (EN)
ANTIBODIES (EN)
Sjogren's syndrome (EN)
AUTOIMMUNE RHEUMATIC-DISEASES (EN)
primary biliary cirrhosis (EN)
antimitochondrial autoantibodies (EN)
chronic liver disease (EN)
SICCA SYNDROME (EN)
ARTHRITIS (EN)
LIVER INVOLVEMENT (EN)
FEATURES (EN)

JOURNAL OF RHEUMATOLOGY (EN)

Αγγλική γλώσσα

J RHEUMATOL PUBL CO (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.