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Biodistribution and scintigraphic studies of 153Sm-labeled anti-CEA monoclonal antibody for radioimmunoscintigraphy and radioimmunotherapy

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National Technical University of Athens   

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Biodistribution and scintigraphic studies of 153Sm-labeled anti-CEA monoclonal antibody for radioimmunoscintigraphy and radioimmunotherapy (EN)
Archimandritis, SC (EN)
Xanthopoulos, S (EN)
Bouziotis, P (EN)
Fani, M (EN)
Varvarigou, AD (EN)
Stratis, N (EN)
Loudos, G (EN)
conferenceItem (EN)
2014-03-01T02:42:12Z
2003 (EN)
The anti-CEA monoclonal antibody, which selectively localizes in colon cancer, was labeled with Samaritan-153 (Sm-153). Sm-153 is mainly a beta-emitter which can be used for therapeutic purposes, while its gamma-ray facilitates imaging studies. Labeling was achieved using the bicyclic anhydride of DTPA as chelator for Sm-153 tagging onto the antibody. [153Sm]anti-CEA was biologically evaluated in nude mice bearing tumors of different weight (0.5-2.5g), at diverse time intervals (4-72 hours), by anatomic and imaging methods. Biodistribution studies showed slow blood clearance and high retention in the liver, kidneys and lungs. In nude mice bearing tumors of about the same weight. uptake increased with time, from 4 to 72 hours post injection (p.i.). Highest uptake was observed in 0.5-0.8g tumors compared to those of 1.5-2.5g. The results agreed with imaging studies performed on a gamma camera at 4 to 72 hours p.i. Tumor uptake depended on time and tumor weight. The tumor can be visualized 24 hours p.i. but, due to the high background, it can be clearly distinguished at 72 hours p.i. (EN)
Oncology (EN)
acid anhydride (EN)
Radioisotopes (EN)
tissue distribution (EN)
evaluation (EN)
Tissue Distribution (EN)
Radioimmunoscintigraphy (EN)
kidney (EN)
mouse (EN)
pentetic acid (EN)
drug uptake (EN)
animal model (EN)
female (EN)
Radiopharmaceuticals (EN)
radioactivity (EN)
liver (EN)
human cell (EN)
animal experiment (EN)
diagnostic imaging (EN)
lung (EN)
conference paper (EN)
Immunoconjugates (EN)
chelating agent (EN)
Mice, Nude (EN)
Samarium-153 (EN)
animal tissue (EN)
plasma clearance (EN)
nonhuman (EN)
Mice (EN)
isotope labeling (EN)
immunoscintigraphy (EN)
drug clearance (EN)
gamma radiation (EN)
Anti-CEA monoclonal antibody (EN)
radioimmunotherapy (EN)
tumor volume (EN)
scintillation camera (EN)
antibody specificity (EN)
parameter (EN)
Female (EN)
priority journal (EN)
Samarium (EN)
human (EN)
nude mouse (EN)
antibody labeling (EN)
antigen expression (EN)
colon cancer (EN)
Radioimmunotherapy (EN)
reticuloendothelial system (EN)
bioaccumulation (EN)
Antibodies, Monoclonal (EN)
carcinoembryonic antibody (EN)
drug targeting (EN)
samarium 153 (EN)
Animals (EN)
controlled study (EN)
antigen antibody reaction (EN)
drug distribution (EN)
Carcinoembryonic Antigen (EN)
monoclonal antibody (EN)
Anticancer Research (EN)
English
INT INST ANTICANCER RESEARCH (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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