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Study of autoantibodies in groups of healthy women in different ages

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National Archive of PhD Theses  | ΕΚΤ NA.Ph.D.   

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Μελέτη αυτοαντισωμάτων σε διάφορες ηλικιακές oμάδες υγειών γυναικών
Study of autoantibodies in groups of healthy women in different ages
Hatzipetrou, Petros
Χατζηπέτρου, Πέτρος
PhD Thesis
1999
THE PURPOSE OF THIS STUDY WAS TO COMPARE THE PREVANCE OF AUTOANTIBODIES IN A HEALTHY PREGNANT POPULATION TO THAT OF A CONTROL NON-PREGNANT GROUP AND TO DETERMINE WHETHER PREGNANCY INFLUENCES THE AUTOANTIBODY PRODUCTION. OUR RESULTS SHOWED THAT PREGNANT WOMEN HAVE A SIGNIFICANTLY LOWER PREVALENCE OF AUTOANTIBODIES COMPARED TO A HEALTHY MATCHED CONTROL POPULATION. IN OUR STUDY HIGHLY SENSITIVE AND SPECIFIC ΕLISA METHODS AND A WIDELY APPROVED COUNTERIMIN UNOELECTROPHORESIS METHOD WERE USED FOR THE DETECTION OF AUTOANTIBODIES. OUR RESULTS SUGGEST THAT: A)THE PREVALENCE OF AUTOANTIBODIES DECREASE DURING PREGNANCY. B)THE PRESENCE OF ANTI-CARDIOLIPIN ANTIBODIES, ANTI-DS DNA AND ANTI-RO(SS-A) ANTIBODIES IN HEALTHY PREGNANTI WOMEN DOES NOT CORRELATE WITH ANY PREGNANCY RELATED COMPLICATIONS. C)THE DETECTION OF ANTIPHOSPHOLIPID ANTIBODIES IN ESPECIALLY HIGH TITRES MAY BE POSSIBLY CORRELATED TO AN INCREASED RISK OF SPONTANEOUS ABORTIONS. D)UNTIL DEFINITE CONCLUSIONS CAN BE DRAWN, BY THEUSE OF HIGH SENSITIVITY METHODS LIKE THOSE WHICH WERE USED IN THE PRESENT STUDY, THE EVALUATION OF LEVELS OF ANTICARDIOLIPIN ANTIBODIES MAY BE IMPORTANT IN THE OBSERVATION OF PREGNANCY AND ESPECIALLY IN THOSE CASES WITH HIGH RISK OF SPONTANEOUS ABORTIONS. OUR RESULTS ARE IN CONTRAST WITH PREVIOUS REPORTS WHICH SHOWED AN INCREASED PREVALENCE OF AUTOANTIBODY DETECTION IN A "NORMAL" HEALTHY PREGNANT POPULATION.
ΣΤΗΝ ΜΕΛΕΤΗ ΑΥΤΗ ΣΥΓΚΡΙΘΗΚΕ Η ΕΠΙΚΡΑΤΗΣΗ ΤΩΝ ΑΥΤΟΑΝΤΙΣΩΜΑΤΩΝ ΣΕ ΕΝΑ ΥΓΙΗ ΠΛΗΘΥΣΜΟ ΕΓΚΥΩΝ ΓΥΝΑΙΚΩΝ ΣΕ ΣΥΓΚΡΙΣΗ ΜΕ ΜΙΑ ΟΜΑΔΑ ΕΛΕΓΧΟΥ ΜΗ ΕΓΚΥΩΝ, ΚΑΙ ΕΓΙΝΕ ΠΡΟΣΠΑΘΕΙΑ ΝΑ ΚΑΘΟΡΙΣΘΕΙ ΣΕ ΠΟΙΟ ΒΑΘΜΟ
Κλινική Ιατρική
Ιατρική και Επιστήμες Υγείας
Autoimmunity
Pregnancy
Κύηση
Clinical Medicine
Autoantibodies
Medical and Health Sciences
Αυτοανοσία
Αυτοαντισώματα
Κλινική Ιατρική
Antiphospholipid antibodies
Αντιφωσφολιπιδικά αντισώματα
Ιατρική και Επιστήμες Υγείας
Greek
Πανεπιστήμιο Ιωαννίνων
University of Ioannina
Πανεπιστήμιο Ιωαννίνων. Σχολή Ιατρικής. Τμήμα Ιατρικής. Τομέας Παθολογικός. Κλινική Ρευματολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων
National Documentation Centre (EKT)
National Archive of PhD Theses
Συλλογή ΕΑΔΔ



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