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Investigation of the possiblemediating role of the heat shock proteins between psychophysiological stress and organic disease: the case of inflammatory bowel disease

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Διερεύνηση του πιθανού διαμεσολαβητικού ρόλου των πρωτεϊνών θερμικού shock ανάμεσα στο ψυχοφυσιολογικό στρες και τις οργανικές παθήσεις: η περίπτωση των ιδιοπαθών φλεγμονωδών νόσων του εντέρου
Investigation of the possiblemediating role of the heat shock proteins between psychophysiological stress and organic disease: the case of inflammatory bowel disease
Vlachos, Ilias
Βλάχος, Ηλίας
PhD Thesis
2013
Objective – To investigate the hypothesis that depression and anxiety levelscould beassociatedwith theinduction of theantiapoptoticHeatShock Protein70 (HSP70) inthe colon of patients with Inflammatory Bowel Diseases (IBD),namelyulcerativecolitis(UC)andCrohn‟sdisease(CD).Methods- 54 consecutive, hospitalized IBD patients in relapse gave theirinformed consent, filled out psychometric questionnaires [Zung DepressionRatingScale(ZDRS),SpielbergerState-TraitAnxietyInventory(STAIFormXI,IIas a state andas a trait), Hospital Anxiety and Depression Scale (HADS)].Simultaneously, intestinal biopsies were taken to be diagnosed in a blindedmanner by two pathologists. The type and severity of inflammation wereassessedoneachsection withhematoxylin/eosinstaining.Thelocalizationandintensity of expression ofHSP70 expression were studiedimmunohistochemically.Results:31/54patientssufferedfromactiveUC,14fromCDand9wereinremission.InducibleHSP70(HSP70i)wasscarcelydetectableintheintestinalmucosa of UC and CD patients. There was statistically significant correlationbetween depression and anxiety levels and inducible HSP70 in thepolymorphonuclearcells(PMN)ofpatientswithactiveUC.Conclusion: Inducible HSP70 is clearly expressed in PMN cells of IBD patientsand in patients with active UC this finding positively correlates with thedepression and anxiety levels. Given the antiapoptotic, cytoprotective effect ofHSP70onPMNcells and thedestructiverole thatPMNcellsexertonintestinalmucosa of IBD patients, light could be shed on the psychosomatic aspect ofautoimmunityinthesediseases.
Ιατρική και Επιστήμες Υγείας ➨ Κλινική Ιατρική
Πρωτεΐνες θερμικού shock
Ιδιοπαθείς φλεγμονώδεις νόσοι εντέρου
Medical and Health Sciences
Πολυμορφοπύρηνα κύτταρα
Heat shock proteins
Depression
Psychoneuroimmunology
Κλινική Ιατρική
Clinical Medicine
Ψυχονευροανοσολογία
Polymorphonuclear cells
Anxiety
Inflammatory bowel diseases (IBD)
Άγχος
Κατάθλιψη
Ιατρική και Επιστήμες Υγείας
Greek
National and Kapodistrian University of Athens
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής. Τομέας Κλινικοεργαστηριακός. Εργαστήριο Α' Παθολογικής Ανατομικής
National Documentation Centre (EKT)
National Archive of PhD Theses
Συλλογή ΕΑΔΔ



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