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Δείκτες παρακολούθησης και πρόγνωσης στην ιδιοπαθή πνευμονική ίνωση

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Prognostic markers of survival in idiopathic pulmonary fibrosis
Δείκτες παρακολούθησης και πρόγνωσης στην ιδιοπαθή πνευμονική ίνωση
Triantafillidou, Christina
Τριανταφυλλίδου, Χριστίνα
PhD Thesis
2013
Background: In Idiopathic Pulmonary Fibrosis (IPF) irreversibly progressive fibrosingparenchymal damage, leads to defects in mechanics and gas exchange, manifesting withdisabling exertional dyspnea. Previous studies have shown a relationship betweenfibroblast foci (FF) profusion and disease severity and survival. We hypothesized arelationship between Medical Research Council (MRC) dyspnea scale with FF, and arelationship between FF and functional parameters and survival.Methods: We retrospectively reviewed 24 histologically documented IPF patients.Profusion of FF was semiquantitatively evaluated by two scores, Brompton andMichigan. Survival analysis was performed by fitting Cox regression models toexamine the relationship of the two scores with survival and the non-parametricSpearman correlation coefficient was calculated to describe the relationships of FFscores with dyspnea scores and functional parameters.Results: No statistically significant correlation between FF scores and the MRC scoreswas observed (p = 0.96 and p = 0.508 respectively). No significant correlation betweenFF scores and survival (p = 0.438 and p = 0.861 respectively) or any functionalparameter was observed.Conclusions: The lack of relationship between the MRC dyspnea scale and the FFmight relate to the fact that dyspnea in IPF better reflects the overall of lung damageand its related consequences on mechanics and gas exchange whereas FF, one of itshistological hallmarks, may not reflect its entire histology derangement also constrainedby the geographically limited sampled tissue. This might be also valid for the observedlack of association between FF and survival or functional parameters.
Ιατρική και Επιστήμες Υγείας ➨ Κλινική Ιατρική
6 minute walk test
Παθολογοανατομικοί δείκτες βαρύτητας
Medical and Health Sciences
Κλινική Ιατρική
Δύσπνοια κοπώσεως
Καρδιοαναπνευστική δοκιμασία κοπώσεως
Survival
Επιβίωση
Ιδιοπαθής πνευμονική ίνωση
Pathologic prognostic factors
Clinical Medicine
Exercise testing
Cardiopulmonary exercise test
Δοκιμασία βάδισης 6 λεπτών
Ινοβλαστικές εστίες
Idiopathic pulmonary fibrosis (IPF)
Dyspnea in exertion
Δοκιμασίες άσκησης
Ιατρική και Επιστήμες Υγείας
Greek
National and Kapodistrian University of Athens
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής. Τομέας Παθολογίας. Κλινική Β' Πανεπιστημιακή Πνευμονολογική Νοσοκομείου ΑΤΤΙΚΟΝ
National Documentation Centre (EKT)
National Archive of PhD Theses
Συλλογή ΕΑΔΔ



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