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Η επίδραση της προποφόλης στην αναπνευστική λειτουργία μετά από οξεία εντερική ισχαιμία: πειραματική μελέτη

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Η επίδραση της προποφόλης στην αναπνευστική λειτουργία μετά από οξεία εντερική ισχαιμία: πειραματική μελέτη
Vasileiou, Ioanna
Βασιλείου, Ιωάννα
PhD Thesis
2013
Background: The antioxidant properties of propofol have been shown to improve ischemia/reperfusion injury. We investigated whether anesthesia with propofol can ameliorate remote lung injury induced by intestinal ischemia-reperfusion (IIR). Materials & Methods: Thirty male Wistar rats were randomly allocated in 3 groups (n=10 each): Animals in group SHAM were anesthetized with ketamine and xylazine and then laparotomy and sham IIR followed. Animals in group IIR received ketamine and xylazine and were then subjected to clamping of the superior mesenteric artery for 45 min and reperfusion for 4 hours. Group IIR+P received anesthesia with propofol and then IIR was induced, as in group IIR. Blood samples for blood gases and malondialdehyde measurement were drawn at the end of reperfusion. Bronchoalveolar lavage fluid (BALF) was obtained to measure cell counts, total protein and phospholipids levels. Results: Induction of IIR resulted in deteriorated oxygenation, acidemia and inflammatory cells sequestration, along with increased BALF protein content and increased proportions of small surfactant aggregates. Anesthesia with propofol alleviated intestinal injury and efficiently prevented lipid oxidation. In group IIR+P inflammatory cells infiltration and pulmonary histological changes were significantly limited. The increase in BALF total protein and the changes in surfactant aggregates were prevented, leading to normal systemic oxygenation. Conclusion: Using propofol to induce and maintain anesthesia efficiently prevented IIR-induced lung injury. Systemic antioxidant protection, improvement of intestinal injury, inhibition of the inflammatory response and preservation of the alveolar-capillary permeability seem to be crucial mediating mechanisms for this simple and clinically relevant intervention.
Ιατρική και Επιστήμες Υγείας ➨ Βασική Ιατρική
Ιατρική και Επιστήμες Υγείας ➨ Κλινική Ιατρική
Επιφανειοδραστικόs παράγοντας
Oxidative stress
Basic Medicine
Medical and Health Sciences
Κλινική Ιατρική
Surfactant
Ισχαμία - επαναιμάτωση
Προποφόλη
Clinical Medicine
Οξειδωτικό stess
Βασική Ιατρική
Propofol
Οξεία πνευμονική βλάβη
Intestinal ischemia - reperfusion
Ιατρική και Επιστήμες Υγείας
Lung injury
Greek
National and Kapodistrian University of Athens
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής. Τομέας Χειρουργικής. Κλινική Β' Πανεπιστημιακή Αναισθησιολογίας
National Documentation Centre (EKT)
National Archive of PhD Theses
Συλλογή ΕΑΔΔ



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