2-amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues

 
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2-amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues (EN)

Bissyris, E. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Bissyris, E. (EN)

2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid (4) (ATPC) is an unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics. ATPC was obtained from both 3a and 3b thienopyrimidines by hydrolysis and hydrogenolysis, respectively. The synthesis of eleven ATPC-amino acids and two ATPC-peptides is described. ATPC is incorporated as N-terminal moiety in solution or solid-phase peptide synthesis using Boc or Fmoc methodology and without protection of the ATPC amino group. (EN)

heterocycles (EN)


Synthesis-Stuttgart (EN)

English

2005


Thieme Publishing (EN)



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