Metal complexes with 2-(alpha-hydroxy-benzyl)thiamin pyrophosphate (HBTPP). Models for metal binding of thiamin enzymes

 
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1999 (EN)
Metal complexes with 2-(alpha-hydroxy-benzyl)thiamin pyrophosphate (HBTPP). Models for metal binding of thiamin enzymes (EN)

Dodi, K. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Dodi, K. (EN)

The reactions of MCl2 (M=Zn2+, Cd2+, Hg2+) With 2-(alpha-hydrOXy-benzyl)thiamin pyrophosphate (HBTPP) at various pH values (different protonation states) were studied in methanolic solutions. Solid complexes of formulae {K[Zn(HBTPP)Cl--(2)] . H2O}(m), {K-2[Cd(HBTPP)Cl-2-(2)] . 3H(2)O}(n), K-2[Hg(HBTPP)(2)-Cl-2] . 3H(2)O and Zn(HBTPP)(2)Cl-0(2) were isolated and characterized by elemental analysis and various NMR techniques, namely C-13 NMR, P-31 NMR, Cd-113 NMR, Hg-199 NMR and H-1 NMR ROESY spectra in D2O. The data provide evidence that Zn(II) in {K[Zn(HBTPP)Cl--(2)] . H2O}(n), and Cd(II) in {K-2[Cd(HBTPP)Cl-2-(2)] . 3H(2)O}(n), are coordinated both to the pyrimidine N(1') and to the pyrophosphate group. In contrast, Hg(II) in K-2[Hg(HBTPP)(2)Cl--(2)] . 3H(2)O and Zn(II) in Zn(HBTPP)(2)Cl-0(2) are bound only to the N(1') atom or to the pyrophosphate group, respectively. (C) 1999 Elsevier Science Inc. All rights reserved. (EN)

thiamin enzymes (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

J Inorg Biochem (EN)

English

1999

<Go to ISI>://000079589800006

Elsevier (EN)



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