A comparative study on cytogenetic and antineoplastic effects induced by two modified steroidal alkylating agents
Geromichalos, Georgios D.
We investigated the effects of two newly synthesized steroidal derivatives of nitrogen mustard on sister chromatid exchange rates and on human lymphocyte proliferation kinetics. The compound 3 beta -hydroxy-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(1) was. on a molar basis, less effective in inducing sister chromatid exchange and suppressing cell proliferation rate indices than compound 3 beta -hydroxy-12 alpha -aza-C-homo-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(2). A correlation was observed between the magnitude of the sister chromatid exchange response and the depression of cell proliferation index. We also studied the effects of the aforementioned compounds on Lewis lung carcinoma. The order of the percent inhibition of tumor growth achieved by the compounds coincides with the order of the cytogenetic effects they induce.
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής
Cancer Detection and Prevention, vol.25  p.369-374 [Published Version]
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