A comparative study on cytogenetic and antineoplastic effects induced by two modified steroidal alkylating agents

 
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A comparative study on cytogenetic and antineoplastic effects induced by two modified steroidal alkylating agents

Mourelatos, Dionysios
Chrysogelou, Eleni
Kotsis, Alexandros
Geromichalos, Georgios D.
Houvartas, S.
Tsavdaridis, Dimitrios
Papageorgiou, Athanasios
Karamperis, Stergios
Camoutsis, Charalambos

We investigated the effects of two newly synthesized steroidal derivatives of nitrogen mustard on sister chromatid exchange rates and on human lymphocyte proliferation kinetics. The compound 3 beta -hydroxy-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(1) was. on a molar basis, less effective in inducing sister chromatid exchange and suppressing cell proliferation rate indices than compound 3 beta -hydroxy-12 alpha -aza-C-homo-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(2). A correlation was observed between the magnitude of the sister chromatid exchange response and the depression of cell proliferation index. We also studied the effects of the aforementioned compounds on Lewis lung carcinoma. The order of the percent inhibition of tumor growth achieved by the compounds coincides with the order of the cytogenetic effects they induce.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

Αγγλική γλώσσα

2001
2009-07-17T11:23:46Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Cancer Detection and Prevention, vol.25 [2001] p.369-374 [Published Version]
urn:ISSN:0361090X

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info:eu-repo/semantics/openAccess



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