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5 alpha,8 alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity

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5 alpha,8 alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity
Roussis, Vassilios
Vagias, Constantinos
Christofidis, Dimitrios
Alexi, Xanthippi
Αλέξης, Μιχαήλ Ν.
Ioannou, Efstathia
Abdel-Razik, Ayman F.
Ζερβού, Μαρία
Άρθρο σε επιστημονικό περιοδικό
2009-01
NEW YORK
Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5 alpha,8 alpha-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity.
Εσωτερική ιατρική (EL)
Βιολογία (Γενικά) (EL)
Biology (General) (EN)
Internal medicine (EN)
Trididemnum inarmatum
Antiproliferative activity
5 alpha,8 alpha-Epidioxysterols
Endocrinology & Metabolism
Eunicella cavolini
Structure elucidation
English
Elsevier Inc.
Steroids
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© 2008 Elsevier Inc. All rights reserved.
© 2008 Elsevier Inc. All rights reserved. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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