1. Home page
  2. Search

Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines

This item is provided by the institution :
National Hellenic Research Foundation (NHRF)   

Repository :
Helios - Repository of the National Hellenic Research Foundation (NHRF)  | repositories EKT   

see the original item page
in the repository's web site and access all digital files if the item*



Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines
Schwager, Christian
Wirkner, Ute
Τρουγκάκος, Ιωάννης Π.
Χονδρογιάννη, Νίκη
Γκόνος, Ευστάθιος
Amarantos, Ioannis
Blake, Jonathon
Ansorge, Wilhelm
Άρθρο σε επιστημονικό περιοδικό
2010-01-15
NEW YORK
With the use of genome-wide cDNA microarrays, we investigated the transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. In all, 1,098 chip entries were differentially regulated in the two cell lines; of these, 796 entries corresponded to characterized mRNAs. The identified genes are mostly expressed in epithelial tissues and localize on chromosomes 1, 10, and 20. Furthermore, signaling cascades for cell cycle, glycolysis, and gluconeogenesis, the p53 pathway, cell communication, and focal adhesion were found to be differently regulated in the two cell lines. The transcriptome profiles reported here provide novel information about the considerable molecular differences between these two widely used human osteosarcoma cell lines.
Βιολογία (Γενικά) (EL)
Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες) (EL)
Biology (General) (EN)
Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) (EN)
Genetics & Heredity
English
Elsevier Inc.
Cancer Genetics and Cytogenetics
https://rightsstatements.org/page/InC/1.0/?language=en
© 2010 Elsevier Inc. All rights reserved.
© 2010 Elsevier Inc. All rights reserved. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)