1. Home page
  2. Search

Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

This item is provided by the institution :
National Hellenic Research Foundation (NHRF)   

Repository :
Helios - Repository of the National Hellenic Research Foundation (NHRF)  | repositories EKT   

see the original item page
in the repository's web site and access all digital files if the item*



Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts
Kontogiorgis, Christos
Detsi, Anastasia
Igglessi-Markopoulou, Olga
Afantitis, Antreas
Κουφάκη, Μαρία
Hadjipavlou-Litina, Dimitra J.
Melagraki, Georgia
Άρθρο σε επιστημονικό περιοδικό
2009-07
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity.
PARIS
Χημεία (Γενικά) (EL)
Φαρμακευτική (EL)
Pharmacy and materia medica (EN)
Chemistry (General) (EN)
Lipoic acid
Coumarins
Antioxidant
Chemistry, Medicinal
Anti-inflammatory
English
Elsevier France, Editions Scientifiques et Medicales
European Journal of Medicinal Chemistry
https://rightsstatements.org/page/InC/1.0/?language=en
© 2009 Elsevier Masson SAS. All rights reserved.
© 2009 Elsevier Masson SAS. All rights reserved. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)