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New Drug Delivery Nanosystem Combining Liposomal and Dendrimeric Technology (Liposomal Locked-In Dendrimers) for Cancer Therapy

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New Drug Delivery Nanosystem Combining Liposomal and Dendrimeric Technology (Liposomal Locked-In Dendrimers) for Cancer Therapy
Μίχα-Σκρέττα, Μαρία
Gardikis, Konstantinos
Bucos, Madalina
Klajnert, Barbara
Demetzos, Costas
Σκρέττας, Κωνσταντίνος Γ.
Bryszewska, Maria
Ionov, Maksim
Στηλ, Μπάρυ
Hatziantoniou, Sophia
Signorelli, Marco
Felekis, Theodoros
Fessas, Dimitrios
Ζερβού, Μαρία
Άρθρο σε επιστημονικό περιοδικό
2010-08
Liposomal locked-in dendrimers (LLDs), the combination of liposomes and dendrimers in one formulation, represents a relatively new term in the drug carrier technology. LLDs undergone appropriate physicochemical investigation can merge the benefits of liposomal and dendrimeric nanocarriers. In this study generation 1 and 2 hydroxy-terminated dendrimers were synthesized and were then "locked" in liposomes consisting of DOPC/DPPG. The anticancer drug doxorubicin (Dox) was loaded Into pure liposomes or LLDs and the final products were subjected to lyophilization. The loading of Dox as well as its in vitro release rate from all systems was determined and the interaction of liposomes with dendrimers was assessed by thermal analysis and fluorescence spectroscopy The results were very promising in terms of drug encapsulation and release rate, factors that can alter the therapeutic profile of a drug with low therapeutic index such as Dox Physicochemical methods revealed a strong, generation dependent, interaction between liposomes and dendrimers that probably is the basis for the higher loading and slower drug release from the LLDs comparing to pure liposomes. 2010 Wiley-Liss, Inc and the American Pharmacists Association J Pharm Sci 99 3561-3571, 2010
MALDEN
Χημεία (Γενικά) (EL)
Φαρμακευτική (EL)
Pharmacy and materia medica (EN)
Chemistry (General) (EN)
in vitro release
differential scanning calorimetry
dendrimer
fluorescence spectroscopy
doxorubicin
Chemistry, Medicinal
Chemistry, Multidisciplinary
liposome
English
John Wiley & Sons, Inc.
Journal of Pharmaceutical Sciences
https://rightsstatements.org/page/InC/1.0/?language=en
© WILEY-BLACKWELL
© WILEY-BLACKWELL (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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