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XANTHONES IN HETEROCYCLIC SYNTHESIS. AN EFFICIENT ROUTE FOR THE SYNTHESIS OF C-3 o-HYDROXYARYL SUBSTITUTED 1,2-BENZISOXAZOLES AND THEIR N-OXIDES, POTENTIAL SCAFFOLDS FOR ANGIOTENSIN(II) ANTAGONIST HYBRID PEPTIDES

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XANTHONES IN HETEROCYCLIC SYNTHESIS. AN EFFICIENT ROUTE FOR THE SYNTHESIS OF C-3 o-HYDROXYARYL SUBSTITUTED 1,2-BENZISOXAZOLES AND THEIR N-OXIDES, POTENTIAL SCAFFOLDS FOR ANGIOTENSIN(II) ANTAGONIST HYBRID PEPTIDES
Gardikis, Yiannis
Tsoungas, Petros G.
Potamitis, Constantinos
Cordopatis, Paul
Ζερβού, Μαρία
Άρθρο σε επιστημονικό περιοδικό
2011-05-01
OXFORD
Regioselective substitution of xanthone and its nucleophilic cleavage allow the synthesis of C-3 o-hydroxyaryl substituted 1,2-benzisoxazoles or their N-oxides by cyclodehydration or oxidative cyclization of their corresponding ketoxime precursors, respectively. Molecular modeling analysis and (1)H NMR spectra indicate an intramolecular H-bonding engaging phenol OH and the isoxazole ring N atom.
Οργανική χημεία (EL)
Organic chemistry (EN)
English
Japan Institute of Heterocyclic Chemistry
Heterocycles
© PERGAMON-ELSEVIER SCIENCE LTD
© PERGAMON-ELSEVIER SCIENCE LTD (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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