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β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study

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β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study
Detsi, Anastasia
Pitterou, Ioanna
Ξενάκης, Αριστοτέλης
Avramiotis, Spyridon
Kourtesi, Chryssa
Chatzidaki, Maria
Kostopoulou, Ioanna
Άρθρο σε επιστημονικό περιοδικό
3000-01-01
2020
Antioxidants are radical scavengers that have been proposed to be involved in many pathological conditions, from aging to degenerative disorders. The aim of the present study is the preparation, structural characterization and antioxidant efficacy evaluation of inclusion complexes (ICs) of two synthetic antioxidants with β-CD. The compounds under study are heterocyclic hybrid molecules, which combine the quinolinone framework and the pyrazoline moiety in one molecular scaffold. The ICs were thoroughly investigated in terms of structure using various techniques such as DLS, NMR, FT-IR, TGA and DSC. The findings revealed a different structural profile between the two ICs. Furthermore, the ICs were examined for their ability to scavenge radicals such as DPPH and 4-hydroxy-TEMPO in ethanol medium. Overall, β-CD could act as a promising host for the synthesized antioxidants as it increases their water solubility without inhibiting their radical scavenging ability.
Χημική τεχνολογία (EL)
Χημεία (Γενικά) (EL)
Chemical technolgy (EN)
Chemistry (General) (EN)
NMR (EN)
Antioxidant activity (EN)
FT-IR (EN)
Quinolinone - pyrazoline hybrids (EN)
Inclusion complex (EN)
English
Colloids and Surfaces A: Physicochemical and Engineering Aspects
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Copyright © 2020 Elsevier B.V. All rights reserved
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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