1. Home page
  2. Search

Autophagy in aging and oxidative stress

This item is provided by the institution :
National Hellenic Research Foundation (NHRF)   

Repository :
Helios - Repository of the National Hellenic Research Foundation (NHRF)  | repositories EKT   

see the original item page
in the repository's web site and access all digital files if the item*



Autophagy in aging and oxidative stress
Χονδρογιάννη, Νίκη
Gioran, Anna
Ranti, Dimitra
Gioran, Anna
Pick, Elah
Χονδρογιάννη, Νίκη (EL)
Chondrogianni, Niki (EN)
Κεφάλαιο βιβλίου
2021
Autophagy is an evolutionarily conserved catabolic process with a fundamental role in cellular content turnover and energy provision. Damaged or aggregated proteins as well as compromised organelles are removed from the cell through the autophagic machinery. Numerous studies have established the protective role of autophagy against the consequences of oxidative stress and specifically in the clearance of oxidized macromolecules and damaged organelles. Additionally, elevated reactive oxygen species (ROS) levels can activate autophagy either via transcriptional or translational modifications, eventually triggering a response that attenuates cell damage. It is also well established that autophagy declines with aging, thereby contributing to the perturbed protein homeostasis. Indeed, impaired autophagy is tightly associated with the early onset of neurodegenerative and age-related diseases. On the other hand, activation of autophagy is sufficient to promote longevity and healthspan across multiple animal models. This chapter summarizes the basic molecular mechanisms underlying autophagy and focuses on its roles in oxidative stress and aging.
Boca Raton (EN)
Κυτταρολογία (EL)
Βιολογία (Γενικά) (EL)
Βιοχημεία (EL)
Χημική Βιολογία (EL)
Biology (General) (EN)
Cytology (EN)
Chemical Biology (EN)
Biochemistry (EN)
Mitochondria (EL)
Age-related diseases (EL)
Proteasome (EL)
Oxidative stress (EN)
Neurodegenerative diseases (EN)
Reactive oxygen species (ROS) (EN)
Aging (EN)
Longevity (EN)
Autophagy (EN)
English
CRC Press Taylor & Francis
Proteostasis and Proteolysis
Copyright © 2022 Selection and editorial matter, Niki Chondrogianni, Elah Pick and Anna Gioran; Individual chapters, The contributors
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)