1. Home page
  2. Search

[YIA] Proteasome activation in C. elegans causes mild mitochondrial defects; Is this the link to lifespan extension?

This item is provided by the institution :
Εθνικό Ίδρυμα Ερευνών (ΕΙΕ)   

Repository :
Ήλιος - Αποθετήριο Εθνικού Ιδρύματος Ερευνών  | repositories EKT   

see the original item page
in the repository's web site and access all digital files if the item*



[YIA] Proteasome activation in C. elegans causes mild mitochondrial defects; Is this the link to lifespan extension?
Χονδρογιάννη, Νίκη
Gioran, Anna
Περίληψη σε συνέδριο
2022
Our group and others have previously shown that activation of the proteasome, that is responsible for approximately 80% of protein degradation, can prolong the lifespan of C. elegans and D. melanogaster. However, how exactly proteasome activation facilitates lifespan extension, remains unknown. In this study, we have attempted to shed light onto this open question by focusing on the underlying molecular effects of proteasome activation. A proteomic analysis of C. elegans with an activated proteasome revealed differentially regulated glycolysis, a metabolic shift compatible with mitochondrial deficiency.
Δομική Βιολογία (EL)
Βιοχημεία (EL)
Χημική Βιολογία (EL)
Structural Biology (EN)
Chemical Biology (EN)
Biochemistry (EN)
Protein degradation (EN)
Lifespan extension (EN)
Proteasome (EN)
English
Elsevier Inc
Redox Biology Congress 2022, Ghent, East Flanders, Belgium, Free Radical Biology and Medicine, 2022-08-24 - 2022-08-26
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.el
© 2022 Published by Elsevier Inc.
Εθνικό Ίδρυμα Ερευνών (ΕΙΕ)
Ήλιος - Αποθετήριο Εθνικού Ιδρύματος Ερευνών



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)