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New‑onset neuropsychiatric sequelae and 'long‑COVID' syndrome (Review)

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New‑onset neuropsychiatric sequelae and 'long‑COVID' syndrome (Review)
Demetriou, Marina
Tsoporis, James N
Makris, Michael
Σπαντίδος, Δημήτριος Α.
Rizos, Emmanouil
Ferentinos, Panagiotis
Efstathiou, Vasiliki
Stefanou, Maria-Ioanna
Katsantoni, Eleni
Ζουμπουρλής, Βασίλης
Smyrnis, Nikolaos
Siafakas, Nikolaos
Tsivgoulis, Georgios
Kympouropoulos, Stylianos
Άρθρο σε επιστημονικό περιοδικό
2022-11
The ongoing coronavirus disease 2019 (COVID-19) pandemic has had a widespread impact on individuals' mental health through indirect psychological and social mechanisms, related to factors such as fear of infection or death, social isolation, lack of social support and financial instability. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has also been associated with the development or recurrence of neuropsychiatric symptoms, both during the acute phase, as well as during the post-acute 'long-COVID' phase. In addition to the COVID-19 survivors with a mental health history that are at a high risk of experiencing a range of neuropsychiatric symptoms following resolution of acute COVID-19, there is accumulating evidence that a diagnosis of COVID-19 may also be associated with new-onset neuropsychiatric morbidity among survivors without pre-existing mental health disorders. In particular, studies investigating the incidence of post-acute neuropsychiatric sequelae, based mostly on retrospective cohort study designs and data from national health registries, have reported the development of new-onset manifestations, including depression, anxiety, psychotic symptoms, sleep disturbances and fatigue. Nevertheless, when COVID-19 survivors were compared with SARS-CoV-2-negative controls and especially survivors of other disorders (such as influenza), the findings regarding the risk of incident neuropsychiatric manifestations varied among studies. While there is evidence of an association between SARS-CoV-2 infection and the subsequent occurrence of new-onset neuropsychiatric symptoms, especially among patients with increased disease severity, further research using methodological approaches less susceptible to confounding bias is required to establish causal relationships.
Φυσιολογία (EL)
Επιδημίες. Επιδημιολογία (EL)
Ιατρική-Δημόσια υγεία (EL)
Ιολογία (EL)
Medicine - public aspects (EN)
Epidemics. Epidemiology (EN)
Physiology (EN)
Virology (EN)
SARS-CoV-2 (EL)
Incidence of neuropsychiatric symptoms (EL)
COVID-19 survivors (EL)
COVID-19 (EN)
Long‑COVID (EN)
Post‑COVID syndrome (EN)
New‑onset neuropsychiatric manifestations (EN)
Experimental and therapeutic medicine
https://creativecommons.org/licenses/by/4.0/deed.el
© Efstathiou et al.
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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