Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study

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Title

Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study (EN)

Creator

Theodoropoulou, Panagiota (EN)

Stathopoulos, Georgios T (EN)

Blackwell, Timothy S (EN)

Moschos, Charalampos (EN)

Kollintza, Androniki (EN)

Magkouta, Sophia (EN)

Kalomenidis, Ioannis (EN)

Sherrill, Taylor P (EN)

Roussos, Charis (EN)

Karabela, Sophia P (EN)

Psallidas, Ioannis (EN)

Contributor

Blackwell, Timothy S (EN)

Sherrill, Taylor P (EN)

Καλομενίδης, Ιωάννης

Καράμπελα, Σοφία Π

Μαγκούτα, Σοφία

Θεοδωροπούλου, Παναγιώτα

Μόσχος, Χαράλαμπος

Ρούσσος, Χάρης

Κολλίντζα, Ανδρονίκη

Ψαλλίδας, Ιωάννης

Σταθόπουλος, Γεώργιος Τ

Type

Journal (paper) (EN)

Partial document
Publication in journal (EN)

Article
Scientific article (EN)

Issued

2011-12-02 (EN)

2011-12-02T08:44:34Z (EN)

2010-03-10 (EN)

Year

2010 (EN)

Description

- (EN)

We have previously shown that nuclear factor (NF)-κB activation of mouse Lewis lung carcinoma (LLC) specifically promotes the induction of malignant pleural effusions (MPE) by these cells. In the present studies we hypothesized that treatment of immunocompetent mice with bortezomib tailored to inhibit cancer cell NF-κB activation and not proliferation specifically inhibits MPE formation by LLC cells. (EN)

Scientific field

Medical and Health Sciences (EN)

Subject

Lewis lung carcinoma (EN)

Καρκίνωμα του πνεύμονα (EN)

Κακοήθης Πλευριτική Συλλογή (EN)

Malignant pleural effusions (EN)

School / Department / Institute

University of Patras ▶ School of Health Sciences
Faculty of Medicine