Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study
Theodoropoulou, Panagiota
Stathopoulos, Georgios T
Blackwell, Timothy S
Moschos, Charalampos
Kollintza, Androniki
Magkouta, Sophia
Kalomenidis, Ioannis
Sherrill, Taylor P
Roussos, Charis
Karabela, Sophia P
Psallidas, Ioannis
Καλομενίδης, Ιωάννης
Καράμπελα, Σοφία Π
Μαγκούτα, Σοφία
Θεοδωροπούλου, Παναγιώτα
Blackwell, Timothy S
Μόσχος, Χαράλαμπος
Ρούσσος, Χάρης
Κολλίντζα, Ανδρονίκη
Sherrill, Taylor P
Ψαλλίδας, Ιωάννης
Σταθόπουλος, Γεώργιος Τ
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We have previously shown that nuclear factor (NF)-κB activation of mouse Lewis lung carcinoma (LLC) specifically promotes the induction of malignant pleural effusions (MPE) by these cells. In the present studies we hypothesized that treatment of immunocompetent mice with bortezomib tailored to inhibit cancer cell NF-κB activation and not proliferation specifically inhibits MPE formation by LLC cells.
