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Radiation chemistry of cis-platinum-nucleotide complexes

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Radiation chemistry of cis-platinum-nucleotide complexes (EN)
Brekoulakis, JS (EN)
Anastassopoulou, JD (EN)
journalArticle (EN)
2014-03-01T01:08:07Z
1990 (EN)
The mechanism of γ-radiolysis of cis-dichlorodiamineplatinum (II) (cis-Platinum) with guanosine-5'-monophosphate (L) complexes in aqueous solutions was investigated. The decomposition limiting yield G (-cis-Pt (NH3)2L2) in deaerated and nitrous oxide saturated solutions, determined by measuring the absorbance at 254 nm, was found to be 0.8 and 1.2, respectively. It was found from HPLC that, upon irradiation of the complexes, guanosine-5'-monophosphate, guanosine and guanine were released. Other products, such as sugarphosphate and sugar, could not be detected with this UV-method. (EN)
Oncology (EN)
Cis-platinum (EN)
guanosine phosphate (EN)
5'-Guanylic Acid (EN)
Chromatography, High Pressure Liquid (EN)
article (EN)
Cisplatin (EN)
radiolysis (EN)
radiation chemistry (EN)
Radiochemistry (EN)
nucleotide complexes (EN)
nonhuman (EN)
priority journal (EN)
cisplatin (EN)
radiosensitizers (EN)
human (EN)
radiochemistry (EN)
Anticancer Research (EN)
English
INT INST ANTICANCER RESEARCH (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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