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A tandem C-acylation-cyclization reaction sequence for the synthesis of new N-acyl-3-substituted 1,8-naphthyridine-2,4,diones

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A tandem C-acylation-cyclization reaction sequence for the synthesis of new N-acyl-3-substituted 1,8-naphthyridine-2,4,diones (EN)
Mitsos, C (EN)
Igglessi-Markopoulou, O (EN)
Zografos, A (EN)
journalArticle (EN)
2014-03-01T01:14:22Z
1999 (EN)
The 2-substituted 4H-pyrido[2,3-d][3,1]oxazin-4-ones (1a, b) react with active methylene compounds, under mild conditions, to produce N-acyl-3- substituted 1,8-naphthyridine-2,4-diones (3-12). In addition the C-acylation key intermediates (3a), (13) and (14) have been isolated and subsequently cyclized to the corresponding 3-substituted 1,8-naphthyridine-2,4-diones (3) and (15). (EN)
Chemistry, Organic (EN)
antibacterial activity (EN)
unclassified drug (EN)
allergic reaction (EN)
quinoline derivative (EN)
drug potency (EN)
drug synthesis (EN)
chemical reaction (EN)
stomach secretion (EN)
acylation (EN)
article (EN)
mammal (EN)
1,8 naphthyridine 2,4 dione (EN)
receptor binding (EN)
naphthyridinone (EN)
antiinflammatory activity (EN)
Heterocycles (EN)
English
PERGAMON-ELSEVIER SCIENCE LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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