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Controlled release systems based on poly(lactic acid). An in vitro and in vivo study

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Controlled release systems based on poly(lactic acid). An in vitro and in vivo study (EN)
Doxastakis, M (EN)
Hatzi, EC (EN)
Andreopoulos, AG (EN)
journalArticle (EN)
2014-03-01T01:15:31Z
2000 (EN)
A new biodegradable delivery system based on poly(lactic acid) has been formulated, with potential applications in sustained antibiotic release against bone infection. The in vitro release of a new quinolone (pefloxacin) from low molecular weight poly(D,L-lactic acid) (Mw = 2 x 10(3)) lasted for 56 d whereas the in vivo delivery lasted 33 d. In both cases, the release rate is controlled by the drug diffusion and the polymer degradation, which seems to be the predominant factor. For the release experiments, discs were prepared from poly (D,L-lactide) (Mw = 2 x 10(4)) with drug loadings of 2% and 10% w/w. It was concluded that pefloxacin concentration remains higher than the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of bone infection. The results indicate that the two different types of poly(lactic acid) can be used effectively in an implantable antibiotic release system. (C) 2000 Kluwer Academic Publishers. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
Controlled Release (EN)
In Vitro Release (EN)
Lactic Acid (EN)
POLY(DL-LACTIDE) (EN)
Low Molecular Weight (EN)
Minimum Inhibitory Concentration (EN)
POLYLACTONES (EN)
Delivery System (EN)
Poly Lactic Acid (EN)
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (EN)
English
KLUWER ACADEMIC PUBL (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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