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Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test

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Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test (EN)
Asvestas, P (EN)
Vasios, C (EN)
Nikolaou, C (EN)
Matsopoulos, GK (EN)
Papageorgiou, C (EN)
Nikita, KS (EN)
Liappas, I (EN)
Rabavilas, A (EN)
Uzunoglu, N (EN)
journalArticle (EN)
2014-03-01T01:16:05Z
2001 (EN)
The P600 component of event-related potentials, believed to be generated by anterior cingulate gyrus and basal ganglia, is considered as an index of aspects of second-pass parsing processes of information processing, having much in common with working memory (WM) systems. Moreover, dysfunction of these brain structures as well as WM deficits have been implicated in the pathophysiology of opioid addicts. The present study is focused on P600 elicited during a WM test in twenty heroin addicts with prolonged abstinence compared with an equal number of healthy controls. The results showed significantly prolonged latencies at right hemisphere, specifically at F rho2 abduction. Moreover, memory performance of patients did not differ from that of normal controls. These findings may indicate that abstinent heroin addicts manifest abnormal aspects of second-pass parsing processes as are reflected by the P600 latencies, elicited during a WM test. Additionally, the P600 might serve as a valuable investigative tool for a more comprehensive understanding of the neurobiological substrate of drug abuse. NeuroReport 12:1773-1778 (C) 2001 Lippincott Williams & Wilkins. (EN)
Neurosciences (EN)
Brain (EN)
P600 (EN)
Heroin Dependence (EN)
Humans (EN)
Memory (EN)
Evoked Potentials (EN)
Event-related potentials (EN)
Male (EN)
Reference Values (EN)
brain function (EN)
Heroin addiction (EN)
right hemisphere (EN)
clinical article (EN)
Time Factors (EN)
working memory (EN)
Adult (EN)
Female (EN)
priority journal (EN)
female (EN)
human (EN)
heroin dependence (EN)
Heroin (EN)
cognition (EN)
psychologic test (EN)
Substance Withdrawal Syndrome (EN)
Abstinence (EN)
diamorphine (EN)
article (EN)
event related potential (EN)
controlled study (EN)
Working memory (EN)
adult (EN)
drug withdrawal (EN)
male (EN)
NeuroReport (EN)
English
LIPPINCOTT WILLIAMS & WILKINS (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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