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Controlled release of salicylic acid from poly(D,L-Lactide)

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Controlled release of salicylic acid from poly(D,L-Lactide) (EN)
Doxastakis, M (EN)
Hatzi, E (EN)
Andreopoulos, AG (EN)
journalArticle (EN)
2014-03-01T01:16:15Z
2001 (EN)
Poly(D,L-Lactide) of high molecular weight (M-v) was prepared by ring-opening bulk polymerization of D,L-Lactide and characterized in terms of M-v, melting point and swelling behavior in buffer solution. Samples of the polymers with low and high M (v) (2000 and 22 000 respectively) loaded with various amounts of salicylic acid (SA) were immersed in a buffer solution and the release of SA was recorded. The results obtained showed that swelling of the poly(D,L-Lactide) samples obeyed Fick's law, especially for those with high molecular weight, where biodegradation proceeds slowly. The release of SA seemed to follow a simplified relationship which is linear with time, at least for the early stages of delivery. The extent of linearity is dependent on the content of the acidic SA, which probably accelerates decomposition of the high molecular weight products. (C) 2001 Kluwer Academic Publishers. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
polymerization (EN)
melting point (EN)
controlled drug release (EN)
molecular size (EN)
biodegradation (EN)
salicylic acid (EN)
molecular weight (EN)
article (EN)
Controlled Release (EN)
Salicylic Acid (EN)
acidity (EN)
linear system (EN)
High Molecular Weight (EN)
buffer (EN)
polylactide (EN)
priority journal (EN)
Journal of Materials Science: Materials in Medicine (EN)
English
KLUWER ACADEMIC PUBL (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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