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Is external palliative radiotherapy for gallbladder carcinoma effective?

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National Technical University of Athens   

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Is external palliative radiotherapy for gallbladder carcinoma effective? (EN)
Pistevou-Gombaki, K (EN)
Sofroniadis, I (EN)
Eleftheriadis, N (EN)
Plataniotis, G (EN)
Kouloulias, V (EN)
journalArticle (EN)
2014-03-01T01:16:39Z
2001 (EN)
Background: Gallbladder carcinoma is characterized by delayed diagnosis, ineffective treatment and poor prognosis. Surgical resection has been thought to be the treatment of choice, while the role of radiotherapy as adjuvant or palliative treatment has not been fully clarified in the literature. Patient and Methods: We present the case of a 45-year-old female, with unresectable gallbladder carcinoma, grade IV, histologically diagnosed during laparotomy. The patient was treated with palliative intent with percutaneous transhepatic biliary drainage. Furthermore, she received external radiotherapy by Co-60, using a three-field technique (anterior-posterior and right lateral). The total dose was 3,000 cGy in 10 fractions, with 300 cGy per fraction, 5 days weekly. Results: The patient showed clinico-laboratory improvement and was discharged with a permanent percutaneous transhepatic endoprosthesis. During follow-up (10 and 12 months postirradiation), abdominal CTs showed no local extension of the tumor, while the patient had a good performance status. So far, 1 year after the diagnosis of gallbladder cancer she is still alive. Conclusions: External radiotherapy seems to be a safe and effective method of palliative management of gallbladder carcinoma. However, further studies are necessary to determine the role of radiotherapy in palliative or adjuvant treatment of gallbladder carcinoma. (EN)
Oncology (EN)
Follow-Up Studies (EN)
Palliation (EN)
hospital discharge (EN)
Humans (EN)
Middle Aged (EN)
case report (EN)
Palliative Care (EN)
Tomography, X-Ray Computed (EN)
bile duct prosthesis (EN)
Radioisotope Teletherapy (EN)
follow up (EN)
cancer palliative therapy (EN)
cancer radiotherapy (EN)
tumor localization (EN)
External radiotherapy (EN)
Female (EN)
radiation dose (EN)
female (EN)
computer assisted tomography (EN)
human (EN)
Radiotherapy Planning, Computer-Assisted (EN)
disease course (EN)
treatment outcome (EN)
Gallbladder cancer (EN)
cobalt 60 (EN)
article (EN)
cancer staging (EN)
percutaneous transhepatic drainage (EN)
Gallbladder Neoplasms (EN)
adult (EN)
cancer regression (EN)
gallbladder carcinoma (EN)
Neoplasm Staging (EN)
Cobalt Radioisotopes (EN)
Onkologie (EN)
English
KARGER (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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