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Xanthan gum as a carrier for controlled release of drugs

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National Technical University of Athens   

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Xanthan gum as a carrier for controlled release of drugs (EN)
Tarantili, PA (EN)
Andreopoulos, AG (EN)
journalArticle (EN)
2014-03-01T01:17:19Z
2001 (EN)
Systems based on xanthan gum matrix containing 1%, 2% and 5% salicylic acid were prepared and studied as controlled release devices. Swelling of the matrix in distilled water and buffer solutions showed that the ionic strength of the liquid has a strong effect on the sorptive properties of the matrix. From the release experiments, conducted in distilled water at 37 +/-0.5 degreesC, it was found that the drug delivery process was accomplished within the first 10 hours after immersion and salicylic acid was always released via a non-Fickian transport. The phenomenon can be described by a release exponent (n) in the area of 0.77 independently of the initial concentration of salicylic acid in the xanthan matrix. These results can be interpreted taking into consideration the dimensional and physical changes of the polymeric matrix during swelling. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
Water (EN)
Polymeric drug carriers (EN)
Tablets (EN)
Xanthan gum (EN)
salicylic acid (EN)
Biopolymers (EN)
Organic acids (EN)
Drug Carriers (EN)
tablet (EN)
Salicylic Acid (EN)
Solutions (EN)
Controlled release (EN)
Salicylic acid (EN)
Pharmacodynamics (EN)
Swelling (EN)
Polysaccharides, Bacterial (EN)
bacterial polysaccharide (EN)
article (EN)
Sorption (EN)
xanthan (EN)
Drug products (EN)
Xanthan gum matrix (EN)
Non Frickian transport (EN)
Polymeric drug carrier (EN)
drug carrier (EN)
Journal of Biomaterials Applications (EN)
English
TECHNOMIC PUBL CO INC (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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