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Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice

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Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice (EN)
Kyriazi, M (EN)
Rallis, M (EN)
Yova, D (EN)
Lima, A (EN)
journalArticle (EN)
2014-03-01T01:23:41Z
2006 (EN)
The bark extract of Pinus Maritima (PBE), a rich in phenolic acids, polyphenols and in particular flavonoids mixture, was examined for skin cancer preventive action that was evaluated in two different experimental animal tumor models induced by ultraviolet radiation (UVR) and combination of UVR with 7,12-dimethylbenz[a]anthracene. Significant decrease in the number of animals bearing tumors and the number of tumors per animal was observed in the PBE treated animals. In the same time significant increase in the viability of these animals was also observed. Furthermore, PBE delayed the appearance of tumors. These results provide strong evidence about the preventive anticancer activity of this extract on non-melanoma skin cancer and its protective effect not only from UVR, but also from more potent carcinogenic agents. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (EN)
Oncology (EN)
chemically induced disorder (EN)
pinus maritima extract (EN)
skin carcinoma (EN)
Melanins (EN)
Male (EN)
mouse (EN)
hairless mouse (EN)
Ultraviolet Rays (EN)
Time Factors (EN)
bark (EN)
papilloma (EN)
plant extract (EN)
skin tumor (EN)
7,12 dimethylbenz[a]anthracene (EN)
animal model (EN)
female (EN)
chemoprophylaxis (EN)
melanoma (EN)
polyphenol (EN)
animal experiment (EN)
article (EN)
genotoxicity (EN)
antineoplastic activity (EN)
Skin Neoplasms (EN)
animal (EN)
9,10-Dimethyl-1,2-benzanthracene (EN)
drug mechanism (EN)
nonhuman (EN)
metabolism (EN)
Mice (EN)
male (EN)
phenol derivative (EN)
Animalia (EN)
Pinus pinaster (EN)
unclassified drug (EN)
pine (EN)
Pine bark extract (EN)
Pinus (EN)
drug inhibition (EN)
Carcinogens (EN)
Pinus maritima (EN)
Female (EN)
Anticarcinogenic Agents (EN)
flavonoid (EN)
priority journal (EN)
radiation injury (EN)
Neoplasms, Radiation-Induced (EN)
Mice, Inbred HRS (EN)
Hairless mice (EN)
antineoplastic agent (EN)
Chemoprevention (EN)
melanin (EN)
Skin carcinogenesis (EN)
carcinogen (EN)
Plant Bark (EN)
dimethylbenz[a]anthracene (EN)
ultraviolet radiation (EN)
skin carcinogenesis (EN)
Animals (EN)
controlled study (EN)
time (EN)
Cancer Letters (EN)
English
ELSEVIER IRELAND LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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