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Regioselective ring opening of thiomalic acid anhydrides by carbon nucleophiles. Synthesis and X-ray structure elucidation of novel thiophenone derivatives

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Regioselective ring opening of thiomalic acid anhydrides by carbon nucleophiles. Synthesis and X-ray structure elucidation of novel thiophenone derivatives (EN)
Kikionis, S (EN)
McKee, V (EN)
Markopoulos, J (EN)
Igglessi-Markopoulou, O (EN)
journalArticle (EN)
2014-03-01T01:31:47Z
2009 (EN)
Novel and promising thiophenone derivatives were synthesised by regioselective ring opening of activated thiomalic acid anhydrides, with a variety of active methylene nucleophiles via a C-acylation/cyclisation process involving an S-C bond formation. This regioselective approach could be moreover established by X-ray diffraction structure analysis. The thiolactone ring can act as valuable synthetic scaffold for the preparation of natural and synthetic compounds with important biological and pharmacological activities. (C) 2009 Elsevier Ltd. All rights reserved. (EN)
Chemistry, Organic (EN)
unclassified drug (EN)
biological activity (EN)
thiomalic acid (EN)
acid anhydride (EN)
structure analysis (EN)
carbene (EN)
acylation (EN)
Thiomalic anhydride (EN)
carbon (EN)
Thiolactomycin (EN)
stereochemistry (EN)
priority journal (EN)
thiolactone (EN)
synthesis (EN)
Thiophenone (EN)
Thiolactone (EN)
thiophenone derivative (EN)
chemical bond (EN)
Thiotetronic (EN)
cyclization (EN)
X ray diffraction (EN)
article (EN)
ring opening (EN)
nucleophile (EN)
benzene derivative (EN)
Mercaptosuccinic anhydride (EN)
Tetrahedron (EN)
English
PERGAMON-ELSEVIER SCIENCE LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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