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Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

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Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts (EN)
Melagraki, G (EN)
Koufaki, M (EN)
Kontogiorgis, C (EN)
Detsi, A (EN)
Hadjipavlou-Litina, DJ (EN)
Igglessi-Markopoulou, O (EN)
Afantitis, A (EN)
journalArticle (EN)
2014-03-01T01:32:01Z
2009 (EN)
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity. (C) 2009 Elsevier Masson SAS. All rights reserved. (EN)
Chemistry, Medicinal (EN)
n(2 aminoethyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
Soybeans (EN)
edema (EN)
Male (EN)
antioxidant activity (EN)
Antioxidants (EN)
mouse (EN)
enzyme inhibition (EN)
Thioctic Acid (EN)
structure activity relation (EN)
animal model (EN)
female (EN)
Lipoxygenase Inhibitors (EN)
antiinflammatory agent (EN)
n[2 [4 (1,2 dithiolan 3 yl)butanamido]ethyl] 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide (EN)
n[8 [5 (1,2 dithiolan 3 yl)pentanamido]octyl] 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide (EN)
antioxidant (EN)
rat (EN)
drug design (EN)
drug screening (EN)
n[2 [4 (1,2 dithiolan 3 yl)butanamido]ethyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
n(2 aminoethyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide (EN)
Coumarins (EN)
Rats (EN)
animal experiment (EN)
article (EN)
n[8 [5 (1,2 dithiolan 3 yl)pentanamido]octyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
n(2 aminophenyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
nonhuman (EN)
Anti-inflammatory (EN)
n(8 aminooctyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide (EN)
Lipoic acid (EN)
unclassified drug (EN)
n(6 aminohexyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
Anti-Inflammatory Agents (EN)
drug synthesis (EN)
lipoxygenase (EN)
n(8 octylamino) 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
n(2 aminophenyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide (EN)
Female (EN)
paw edema (EN)
Edema (EN)
n[6 [5 (1,2 dithiolan 3 yl)pentanamido]hexyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide (EN)
thioctic acid (EN)
Antioxidant (EN)
Animals (EN)
controlled study (EN)
antiinflammatory activity (EN)
Lipoxygenase (EN)
European Journal of Medicinal Chemistry (EN)
English
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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