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DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association

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National Technical University of Athens   

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DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association (EN)
Dalamagas, T (EN)
Plomaritou, K (EN)
Koziris, N (EN)
Maragkakis, M (EN)
Kourtis, K (EN)
Gousis, M (EN)
Reczko, M (EN)
Vergoulis, T (EN)
Alexiou, P (EN)
Hatzigeorgiou, AG (EN)
journalArticle (EN)
2014-03-01T01:35:30Z
2011 (EN)
microRNAs (miRNAs) are small endogenous RNA molecules that are implicated in many biological processes through post-transcriptional regulation of gene expression. The DIANA-microT Web server provides a user-friendly interface for comprehensive computational analysis of miRNA targets in human and mouse. The server has now been extended to support predictions for two widely studied species: Drosophila melanogaster and Caenorhabditis elegans. In the updated version, the Web server enables the association of miRNAs to diseases through bibliographic analysis and provides insights for the potential involvement of miRNAs in biological processes. The nomenclature used to describe mature miRNAs along different miRBase versions has been extensively analyzed, and the naming history of each miRNA has been extracted. This enables the identification of miRNA publications regardless of possible nomenclature changes. User interaction has been further refined allowing users to save results that they wish to analyze further. A connection to the UCSC genome browser is now provided, enabling users to easily preview predicted binding sites in comparison to a wide array of genomic tracks, such as single nucleotide polymorphisms. The Web server is publicly accessible in www.microrna.gr/microT-v4. © 2011 The Author(s). (EN)
Biochemistry & Molecular Biology (EN)
web browser (EN)
Disease (EN)
Genetic Association Studies (EN)
single nucleotide polymorphism (EN)
Humans (EN)
genetic association (EN)
client server application (EN)
computer interface (EN)
article (EN)
Caenorhabditis elegans (EN)
nomenclature (EN)
bibliographic database (EN)
Animals (EN)
MicroRNAs (EN)
microRNA (EN)
nonhuman (EN)
Mice (EN)
Software (EN)
Internet (EN)
priority journal (EN)
Bibliography as Topic (EN)
Drosophila melanogaster (EN)
computer prediction (EN)
binding site (EN)
Nucleic Acids Research (EN)
English
OXFORD UNIV PRESS (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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