1. Home page
  2. Search

Electrochemical study of some non-steroidal anti-inflammatory drugs: Solvent effect and antioxidant activity

This item is provided by the institution :
National Technical University of Athens   

Repository :
Digital Library of National Technical University of Athens | Dspace@NTUA   

see the original item page
in the repository's web site and access all digital files if the item*



Electrochemical study of some non-steroidal anti-inflammatory drugs: Solvent effect and antioxidant activity (EN)
Andreadou, I (EN)
Zikos, N (EN)
Spyropoulou, E (EN)
Tsantili-Kakoulidou, A (EN)
Tsopelas, F (EN)
Ochsenkuhn-Petropoulou, M (EN)
journalArticle (EN)
2014-03-01T01:35:37Z
2011 (EN)
The electrochemical behavior of 12 non-steroidal anti-inflammatory drugs (NSAIDs) was studied by means of cyclic voltammetry at a glassy carbon electrode. The underlying solvent had a considerable effect to the oxidation potentials of the investigated NSAIDs due to the alteration of their polar intermediates' solvation. Oxicams were more capable of electrochemical oxidation, and the influence of both specific and non-specific solute-solvent interactions in their reactivity was confirmed by means of Kamlet-Taft's analysis. Oxicams were further studied by chronoamperometry at the potentials of 300, 500, and 800 mV. The results obtained by the employed electroanalytical techniques were compared with the reactivity of oxicams towards 1,1- diphenyl-2-dipicrylhydrazyl (DPPH). The study showed a correlation of oxicams' amperometric signal at 800 mV with their absolute reaction rate, z with DPPH. © 2010 Springer-Verlag. (EN)
Electrochemistry (EN)
Solvents (EN)
Reaction intermediates (EN)
Oxicams (EN)
DPPH (EN)
Antioxidant activity (EN)
Drug interactions (EN)
Solvent polarity effect (EN)
Voltammetry (EN)
Reaction rates (EN)
Glassy carbon (EN)
Non-steroidal anti-inflammatory drugs (EN)
Cyclic voltammetry (EN)
Glass membrane electrodes (EN)
Antioxidant activities (EN)
Chronoamperometry (EN)
Electrochemical oxidation (EN)
Journal of Solid State Electrochemistry (EN)
English
SPRINGER (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)