ACYLAMINOACETYL DERIVATIVES OF ACTIVE METHYLENE-COMPOUNDS .3. C-ACYLATION REACTIONS VIA THE HIPPURIC-ACID AZLACTONE

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Title

ACYLAMINOACETYL DERIVATIVES OF ACTIVE METHYLENE-COMPOUNDS .3. C-ACYLATION REACTIONS VIA THE HIPPURIC-ACID AZLACTONE (EN)

Creator

KONTONASSIOS, D (EN)

HAMILAKIS, S (EN)

SANDRIS, C (EN)

Type

journalArticle (EN)

Partial document
Publication in journal (EN)

Article
Scientific article (EN)

Issued

2014-03-01T01:42:44Z

1994 (EN)

Year

1994 (EN)

Description

The C-acylation reactions of the active methylene compounds, methyl cyanoacetate and Meldrum's acid, with hippuric acid, using the DCC activation and the mixed anhydride conditions, are shown to proceed through initial formation of 2-phenyl-5(4H)-oxazolone, the hippuric acid azlactone. The conditions of these reactions using the azlactone as the acylating agent were investigated and discussed. (EN)

Scientific field

Chemistry, Organic (EN)

Natural Sciences ▶ Chemical sciences
Organic Chemistry (EN)

Subject

ANHYDRIDES (EN)

SUBSTITUTED TETRAMIC ACIDS (EN)

CYCLIZATION (EN)

Journal

JOURNAL OF HETEROCYCLIC CHEMISTRY (EN)

Language

English

Publisher