EFFECTS OF ASCORBIC-ACID ON TERT-BUTYL HYDROPEROXIDE-INDUCED DEFORMABILITY DECREASE IN HUMAN ERYTHROCYTES

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



EFFECTS OF ASCORBIC-ACID ON TERT-BUTYL HYDROPEROXIDE-INDUCED DEFORMABILITY DECREASE IN HUMAN ERYTHROCYTES (EN)

BARBOUNAKI, S (EN)
KORANTZOPOULOS, P (EN)
GALARIS, D (EN)
YOVA, D (EN)
KOUTSOURIS, D (EN)

journalArticle (EN)

2014-03-01T01:43:50Z
1995 (EN)


Treatment of human erythrocytes with micromolar concentrations of tert-butyl hydroperoxide causes changes in the physical properties of the cells as evidenced by decreased deformability. The deformability changes followed a lag period which was reciprocally related to the concentrations of hydroperoxide. Ascorbic acid was able to delay these changes or reverse them for a period of time. Oxidation of ascorbic acid was observed, under the same conditions, which was correlated to the ability of both oxy- and met-forms of haemoglobin to catalyse the oxidation of ascorbic acid by tert-butyl hydroperoxide. It seems likely that ascorbic acid acts both as inhibitor of the oxidative activation of haemoglobin, which leads to deformability changes and as substrate for the haemoglobin catalysed tert-butyl hydroperoxide decomposition. (EN)

Hematology (EN)

HEMOGLOBIN (EN)
OXIDATION (EN)
LIPID-PEROXIDATION (EN)
CELL TRANSIT ANALYZER (EN)
INJURY (EN)
MUSCLE (EN)
TERT-BUTYL HYDROPEROXIDE (EN)
ASCORBIC ACID (EN)
DAMAGE (EN)
RED CELL DEFORMABILITY (EN)
HUMAN ERYTHROCYTES (EN)
METMYOGLOBIN (EN)
POTENTIAL PROTECTIVE MECHANISM (EN)
SPERM WHALE MYOGLOBIN (EN)

CLINICAL HEMORHEOLOGY (EN)

Αγγλική γλώσσα

PERGAMON-ELSEVIER SCIENCE LTD (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.