1. Home page
  2. Search

EFFECTS OF ASCORBIC-ACID ON TERT-BUTYL HYDROPEROXIDE-INDUCED DEFORMABILITY DECREASE IN HUMAN ERYTHROCYTES

This item is provided by the institution :
National Technical University of Athens   

Repository :
Digital Library of National Technical University of Athens | Dspace@NTUA   

see the original item page
in the repository's web site and access all digital files if the item*



EFFECTS OF ASCORBIC-ACID ON TERT-BUTYL HYDROPEROXIDE-INDUCED DEFORMABILITY DECREASE IN HUMAN ERYTHROCYTES (EN)
BARBOUNAKI, S (EN)
KORANTZOPOULOS, P (EN)
GALARIS, D (EN)
YOVA, D (EN)
KOUTSOURIS, D (EN)
journalArticle (EN)
2014-03-01T01:43:50Z
1995 (EN)
Treatment of human erythrocytes with micromolar concentrations of tert-butyl hydroperoxide causes changes in the physical properties of the cells as evidenced by decreased deformability. The deformability changes followed a lag period which was reciprocally related to the concentrations of hydroperoxide. Ascorbic acid was able to delay these changes or reverse them for a period of time. Oxidation of ascorbic acid was observed, under the same conditions, which was correlated to the ability of both oxy- and met-forms of haemoglobin to catalyse the oxidation of ascorbic acid by tert-butyl hydroperoxide. It seems likely that ascorbic acid acts both as inhibitor of the oxidative activation of haemoglobin, which leads to deformability changes and as substrate for the haemoglobin catalysed tert-butyl hydroperoxide decomposition. (EN)
Hematology (EN)
HEMOGLOBIN (EN)
OXIDATION (EN)
LIPID-PEROXIDATION (EN)
CELL TRANSIT ANALYZER (EN)
INJURY (EN)
MUSCLE (EN)
TERT-BUTYL HYDROPEROXIDE (EN)
ASCORBIC ACID (EN)
DAMAGE (EN)
RED CELL DEFORMABILITY (EN)
HUMAN ERYTHROCYTES (EN)
METMYOGLOBIN (EN)
POTENTIAL PROTECTIVE MECHANISM (EN)
SPERM WHALE MYOGLOBIN (EN)
CLINICAL HEMORHEOLOGY (EN)
English
PERGAMON-ELSEVIER SCIENCE LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)