openarchives.gr | Therapy of Sjogren's syndrome - New aspects and future directions

Therapy of Sjogren's syndrome - New aspects and future directions

URI: https://www.openarchives.gr/aggregator-openarchives/edm/ntua/000011-123456789_25304
RDF/XML JSON-LD

This item is provided by the institution :
National Technical University of Athens

Repository :
Digital Library of National Technical University of Athens | Dspace@NTUA

see the original item page
in the repository's web site and access all digital files if the item^*

Title

Therapy of Sjogren's syndrome - New aspects and future directions (EN)

Creator

Vlachoyiannopoulos, PG (EN)

Type

journalArticle (EN)

Partial document
Publication in journal (EN)

Article
Scientific article (EN)

Issued

2014-03-01T01:47:44Z

1998 (EN)

Year

1998 (EN)

Description

Therapy of Sjogren's syndrome remains empirical and symptomatic. The main goals are to treat the disease related features, especially sicca manifestations, since the immunosuppressive therapy has not given promising results. For the treatment of keratoconjunctivitis sicca: local stimulators of tear secretion, protective bicarbonate buffered solutions, replacement therapy or supportive operative procedures should be tried. For oral manifestations: stimulators of salivary secretion such as pilocarpine, or agents changing the consistency of saliva such as bromhexine orally should be tried. Saliva substitutes have a transient effect. Frequent ingestion of sugar free liquids may help. Oral hygiene is important to avoid oral candidiasis and dental caries. Treatment of parotid gland swelling is not necessary. Pulmonary manifestations include pulmonary infiltrates in perialveolar areas, nodular or cavitary lesions which may represent lymphoma. Hilar adenopathy, solid or cavitary lesions should be biopsed. In case of vasculitis prednisolone 1mg/kg/day with progressive tapering should be tried. Renal involvement is manifested mainly as interstitial disease. Administration of NaHCO3 or sodium citrate is important to prevent acidosis and nephrocalcinosis. Vasculitis, when it is of the leukoclasic form, does not need therapy; when it is manifested with severe major organ involvement corticosteroids and/or cytotoxic therapy should be tried. Lymphoma is treated as in the patients without Sjogren's in close collaboration with the oncology department. (EN)

Scientific field

Medicine, General & Internal (EN)

Medical and Health Sciences ▶ Clinical Medicine
General and Internal Medicine (EN)

Subject

Sjogren's syndrome (EN)

KERATOCONJUNCTIVITIS SICCA (EN)

therapy (EN)

Journal

ANNALES DE MEDECINE INTERNE (EN)

Language

English

Publisher