Hypophysitis superimposed on a non-functioning pituitary adenoma: Diagnostic clinical, endocrine, and radiologic features

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



Hypophysitis superimposed on a non-functioning pituitary adenoma: Diagnostic clinical, endocrine, and radiologic features (EN)

Ballian, N (EN)
Kaltsas, GA (EN)
Chrisoulidou, A (EN)
Nomikos, P (EN)
Samara, C (EN)
Kontogeorgos, G (EN)

journalArticle (EN)

2014-03-01T01:56:29Z
2007 (EN)


Pituitary adenomas are common neo-plasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radiotherapy, can be associated with significant complications. Hence, it is important to consider disorders that could present in a similar manner to the pituitary adenomas, for the which surgery is not the indicated therapeutic approach. We describe herein a 38-yr-old woman who presented with pituitary lesion that considered to be a non-functioning pituitary lesion that was considered to be a non-functioning pituitary adenoma. Due to lack of hormonal deficits and/or compression of adjacent structures, we opted for conservation management and follow-up with consecutive magnetic resonance imaging. Fifteen months after initial diagnosis, considerable enlargement of the lesion was noted, extending mainly superiorly and indenting the potic chiasm. Repeated endocrine investigation revealed partial anterior pituitary insufficiency. The patient underwent trans-sphenoidal resection of the pituitary lesion; histology revealed a null cell pituitary adenoma and lymphocytic hypophysitis (LYH) of the non-neoplastic adenophypophysial gland. Post-operatively, complete anterior and partial posterior pituitary insuffiency developed. This case illustrates the effects of new-onset LYH in a patient with a pre-existing non-functioning pituatary adenoma. Being aware of this rare possibility is important, as enlargement of the pituitary lesion may not be caused by expansion of the pre-existing tumor, but by the onset of LYH of the non-neoplastic pituitary tissue. (EN)

Endocrinology & Metabolism (EN)

pituitary (EN)
MANAGEMENT (EN)
ALPHA-ENOLASE (EN)
ANTIPITUITARY ANTIBODIES (EN)
hypophysitis (EN)
TUMORS (EN)
DEFICIENCY (EN)
LYMPHOCYTIC HYPOPHYSITIS (EN)
adenoma (EN)
DISEASE (EN)
ADENOHYPOPHYSITIS (EN)
AUTOIMMUNE HYPOPHYSITIS (EN)
EXPERIENCE (EN)

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (EN)

Αγγλική γλώσσα

EDITRICE KURTIS S R L (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.