Superficial Siderosis of Central Nervous System Mimicking Multiple Sclerosis

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Title

Superficial Siderosis of Central Nervous System Mimicking Multiple Sclerosis (EN)

Creator

Papadimas, GK (EN)

Evdokimidis, I (EN)

Konstantinopoulou, A (EN)

Kokotis, P (EN)

Zouvelou, V (EN)

Rentzos, M (EN)

Kilidireas, K (EN)

Type

journalArticle (EN)

Partial document
Publication in journal (EN)

Article
Scientific article (EN)

Issued

2014-03-01T01:58:59Z

2009 (EN)

Year

2009 (EN)

Description

Introduction: Superficial siderosis of the central nervous system is a neurologic disorder mainly characterized by cerebellar involvement, myelopathy, neurosensory hearing loss, and possibly progressive cognitive impairment. Root avulsion due to traumatic plexus injury has been recognized as an extremely rare cause of hemosiderin deposition oil leptomeninges and subpial layers of brain and spinal cord parenchyma. Case Report: A 49-year-old mail presented with progressively evolving ataxia and spastic paraparesis. CSF oligoclonal bands were indicative of an underlying inflammatory process and raised the possibility of a demyelinating disorder. However, spinal cord and brain MRI revealed hemosiderin deposition along the entire neuraxis. A rigorous electrophysiologic study confirmed a functional impairment in many different levels of the nervous system. Conclusion: The demonstration of CSF oligoclonal bands in the reported patient implies that inflammation might be involved in the pathogenesis of superficial siderosis. The diagnosis of this newly recognizable entity needs a high clinical suspicion, but further research is needed to fully elucidate the involved mechanisms. (EN)

Scientific field

Clinical Neurology (EN)

Medical and Health Sciences ▶ Clinical Medicine
Clinical Neurology (EN)

Subject

oligoclonal hands (EN)

multiple sclerosis (EN)

superficial siderosis (EN)

Journal

NEUROLOGIST (EN)

Language

English

Publisher