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On the Trityl Method for Peptide Synthesis

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On the Trityl Method for Peptide Synthesis
Stelakatos, G.C. Theodoropoulos, D.M. Zervas, L. Theodoropoulos, D.M.
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
1959
Trityl derivatives of amino acids can be simply and effectively isolated by chloroform extraction of their diethylammonium salts from the tritylation reaction mixture. N, N'-Ditrityl-L-histidine, N-trityl-L-histidine, N'-trityl-L-histidine methyl ester hydrochloride, O-trityl-L-tyrosine benzyl ester hydrochloride, amongst other tritylamino acids, were prepared. Coupling of tritylamino acids and trityldipeptides with amino acid esters was achieved via the carbodiimide method and the phosphorazo method. Trityl dipeptides may alternatively be coupled via the mixed anhydride procedure without any influence of the bulky trityl group. © 1959, American Chemical Society. All rights reserved. (EN)
English
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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