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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design
Deftereos, S.G. Siasos, G. Giannopoulos, G. Vrachatis, D.A. Angelidis, C. Giotaki, S.G. Gargalianos, P. Giamarellou, H. Gogos, C. Daikos, G. Lazanas, M. Lagiou, P. Saroglou, G. Sipsas, N. Tsiodras, S. Chatzigeorgiou, D. Moussas, N. Kotanidou, A. Koulouris, N. Oikonomou, E. Kaoukis, A. Kossyvakis, C. Raisakis, K. Fountoulaki, K. Comis, M. Tsiachris, D. Sarri, E. Theodorakis, A. Martinez-Dolz, L. Sanz-Sánchez, J. Reimers, B. Stefanini, G.G. Cleman, M. Filippou, D. Olympios, C.D. Pyrgakis, V.N. Goudevenos, J. Hahalis, G. Kolettis, T.M. Iliodromitis, E. Tousoulis, D. Stefanadis, C.
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
2020
Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. Results: Trial results will be disseminated through peer-reviewed publications and conference presentations. Conclusion: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790). © 2020 Hellenic Society of Cardiology (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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