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Endometriosis related to family history of malignancies in the Yale series

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Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών   

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Endometriosis related to family history of malignancies in the Yale series
Matalliotakis, I.M. Cakmak, H. Krasonikolakis, G.D. Dermitzaki, D. Fragouli, Y. Vlastos, G. Arici, A.
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
2010
Objective: Recent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis. Study design: A search of medical records at the Yale New Haven Hospital from 1996 to 2002 identified 348 women with endometriosis and 179 women without endometriosis. All the cases were diagnosed by laparoscopy. Demographic characteristics were evaluated in women with positive or negative family history of cancers in women with endometriosis. Results: The overall risk of patients with endometriosis and positive family history of cancers was 7.7 (95% confidence interval 3.8-15.7) (χ2 = 39.8, P < 0.001). Significant excess was observed for ovarian cancer in first- and second-degree relatives (OR = 10.5, 95% CI (2.5-44.2), χ2 = 14.3, P < 0.001), colon cancer (OR = 7.5, 95% CI (2.7-21.1), χ2 = 18.2, P < 0.001) and prostate cancer (OR = 4.5, 95% CI (14-15.3), χ2 = 6.1, P < 0.001). We found similar results in first- and second-degree relatives with ovarian and colon cancer. Moreover, we found similar results regarding the demographic characteristics in women with positive family history of cancers and in women with negative history. Conclusions: These data suggest a familial association of endometriosis with ovarian, colon and prostate cancers. This evidence could support the genetics and molecular similarities between endometriosis and cancer. Future studies will be important to determine a clear genetic link between endometriosis and cancer. © 2009 Elsevier Ltd. All rights reserved. (EN)
Αγγλική γλώσσα
https://creativecommons.org/licenses/by-nc/4.0/
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Πέργαμος
Άρθρο Περιοδικού (Journal Article)



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