1. Home page
  2. Search

Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease

This item is provided by the institution :
/aggregator-openarchives/portal/institutions/uoa   

Repository :
Pergamos Digital Library   

see the original item page
in the repository's web site and access all digital files if the item*



Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease
Poulopoulou, Cornelia Markakis, Loannis Davaki, Panagiota and Tsaltas, Eleftheria Rombos, Antonis Hatzimanolis, Alexandros and Vassilopoulos, Dimitrios
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
2010
In Alzheimer’s disease (AD), potassium channel abnormalities have been reported in both neural and peripheral tissues. Herein, using whole-cell patch-clamp, we demonstrate an aberrant glutamate-dependent modulation of K(V)1.3 channels in T lymphocytes of AD patients. Although intrinsic K(V)1.3 properties in patients were similar to healthy individuals, glutamate (1-1000 mu M) failed to yield the hyperpolarizing shift normally observed in K(V)1.3 steady-state inactivation (-4.4 +/- 2.7 mV in AD vs. -14.3 +/- 2.5 mV in controls, 10 mu M glutamate), resulting in a 4-fold increase of resting channel activity. Specific agonist and antagonist data indicate that this abnormality is due to dysfunction of cognate group II mGluRs. Given that glutamate is present in plasma and that both mGluRs and K(V)1.3 channels regulate T-lymphocyte responsiveness, our finding may account for the presence of immune-associated alterations in AD. Furthermore, if this aberration reflects a corresponding one in neural tissue, it could provide a potential target in AD pathogenesis. (c) 2009 Elsevier Inc. All rights reserved. (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)