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Αθηρωματική νόσος καρωτίδων : υπερηχογραφική και βιοχημική προσέγγιση

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Αθηρωματική νόσος καρωτίδων : υπερηχογραφική και βιοχημική προσέγγιση
Λεχαρέας Συμεών (EL)
born_digital_thesis
Διδακτορική Διατριβή (EL)
Doctoral Dissertation (EN)
2016
Stroke is a leading cause of morbidity and mortality worldwide, and characterization of vulnerable carotid plaque remains the spearhead of scientific research. Plaque destabilization, the key factor that induces the series of events leading to the clinical symptoms of carotid artery disease, is a consequence of complex mechanical, structural and biochemical processes. Novel imaging and molecular markers have been studied as predictors of disease outcome with promising results. The aim of this review is to present the current state of research on the association between ultrasound-derived echogenicity indices and blood parameters indicative of carotid plaque stability and activity. Bibliographic research revealed that there are limited available data. Among the biomarkers studied, those related to oxidative stress, lipoproteins and diabetes/insulin resistance are associated with echolucent plaques, whereas adipokines are associated with echogenic plaques. Biomarkers of inflammation and coagulation have not exhibited any conclusive relationship with plaque echogenicity, and it is not possible to come to any conclusion regarding calcification-, apoptosis- and neo-angiogenesis-related parameters because of the extremely limited bibliographic data (EN)
Greek
Βιβλιοθήκη και Κέντρο Πληροφόρησης » Βιβλιοθήκη Επιστημών Υγείας
Σχολή Επιστημών Υγείας » Τμήμα Ιατρικής » Τομέας Χειρουργικής
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Doctoral Dissertation



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