δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Antianginal efficacy of the combination of trimetazidine-propranolol
compared with isosorbide dinitrate-propranolol in patients with stable
angina
Michaelides, AP
Spiropoulos, K
Dinopoulos, K
Athanasiades, D
and Toutouzaz, P
Trimetazidine is a new anti-ischaemic drug that exerts cytoprotective
effects without modifying coronary blood flow or systemic haemodynamics.
We tested the antianginal efficacy of trimetazidine in combination with
propranolol, using a double-blind isosorbide dinitrate-controlled
design. Male patients (n = 53) with stable, effort-induced angina not
sufficiently controlled with propranolol 40mg 3 times daily received at
random either trimetazidine 20mg 3 times daily (n = 27) or isosorbide
dinitrate 10mg 3 times daily (n = 26) for 2 months. From day 0 to day
60, in both groups, there was a decrease in the average number of
anginal attacks per week (p < 0.01) and in the weekly consumption of
nitroglycerin (p < 0.01), the latter being more decreased in the
trimetazidine group (p < 0.05). On exercise testing, both exercise
duration and rime to I mm ST depression were improved in the
trimetazidine group at day 60 compared with day 0 values (p < 0.001),
while no significant changes were observed in the isosorbide dinitrate
group. The total workload increased significantly more in the
trimetrtzidine group than in the isosorbide dinitrate group for patients
performing the exercise test on a bicycle (n = 31, p < 0.001), but not
on a treadmill (n = 22, p = not significant). We concluded that in
patients with stable induced angina not sufficiently controlled with
propranolol, a better antianginal efficacy was observed with the
addition of trimetazidine than with the addition of isosorbide
dinitrate, and this confirmed the clinical interest in the new
anti-ischaemic drug.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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