δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Analysis of dissolution data using modified versions of Noyes-Whitney
equation and the Weibull function
The aim of the study is to develop modified, branched versions of the
Noyes-Whitney and the Weibull equations, including explicitly the
solubility/dose parameter, for the analysis of dissolution data, which
reach the plateau either at infinite or finite time.
The modified Weibull function is applied to the analysis of experimental
and literature dissolution data. To demonstrate the usefulness of the
mathematical models, two model drugs are used: one highly soluble,
metoprolol, and one relatively insoluble, ibuprofen.
The models were fitted successfully to the data performing better
compared with their classic versions. The advantages of the use of the
models presented are several. They fit better to a large range of
datasets, especially for fast dissolution curves that reach complete
dissolution at a finite time. Also, the modified Weibull presented can
be derived from differential equations, and it has a physical meaning as
opposed to the purely empirical character of the original Weibull
equation. The exponent of the Weibull equation can be attributed to the
heterogeneity of the process and can be explained by fractal kinetics
concepts. Also, the solubility/dose ratio is present explicitly as a
parameter and allows to obtain estimates of the solubility even when the
dissolution data do not reach the solubility level.
The use of the developed branched equations gives better fittings and
specific physical meaning to the dissolution parameters. Also, the
findings underline the fact that even in the simplest, first-order case,
the speed of the dissolution process depends on the dose, a fact of
great importance in biopharmaceutic classification for regulatory
purposes.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Analysis of dissolution data using modified versions of Noyes-Whitney equation and the Weibull function
Analysis of dissolution data using modified versions of Noyes-Whitney equation and the Weibull function
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