δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Quantification of siderophages in bronchoalveolar fluid in transfusional
and primary pulmonary hemosiderosis
Priftis, Kostas N.
Anthracopoulos, Michael B.
Tsakanika,
Constantina
Tapaki, Georgia
Ladis, Vassilis
Bush, Andrew and
Nicolaidou, Polyxeni
Transfusional iron overload may occur in the lungs. We hypothesized that
quantitating siderophages in the bronchoalveolar fluid (BALF) of heavily
transfused patients may prove to be a useful tool in determining lung
iron overload in transfusion-dependent patients. The study included six
patients (7-20 years) with thalassemia major (TM) who had received
multiple blood transfusions, one with hereditary spherocytosis (four
blood transfusions) and one with sickle cell disease (never transfused);
they were compared to three children with idiopathic pulmonary
hemosiderosis (IPH) (2.5-7.0 years) as positive controls. Fiberoptic
bronchoscopy with bronchoalveolar lavage was performed in seven patients
under general anesthesia for elective surgery and the rest were
bronchoscoped electively under sedation. Spirometry was also performed
in eight patients. There was no significant difference between children
with TM and IPH in siderophages as percentage of total count (95% Cl
-31.0to 1.5, P= 0.068). There were positive relationships between both
mean serum ferritin values during the preceding year and the total
number of units of transfused blood, and percent siderophage count among
multiply transfused patients (P=0.010, P=0.052, respectively); similar
findings were noted for the Golde score (P 0.001, P= 0.031,
respectively). None of the patients showed lung function impairment. In
conclusion, in this small study, we found that the BALF of multiply
transfused patients with benign hematological disorders contain similar
numbers of siderophages to that of patients with IPH; this is strongly
suggestive of secondary pulmonary hemosiderosis. The correlation between
the patients’ serum ferritin, and the BALE siderophages suggests that
the later may serve as a marker of pulmonary iron overload in patients
requiring blood transfusion and appear to be more sensitive than
standard pulmonary function tests.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Quantification of siderophages in bronchoalveolar fluid in transfusional and primary pulmonary hemosiderosis
Quantification of siderophages in bronchoalveolar fluid in transfusional and primary pulmonary hemosiderosis
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