δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Safety and tolerability of clarithromycin administered to children at
higher-than-recommended doses
Kafetzis, D. A.
Chantzi, F.
Tigani, G.
Skevaki, C. L.
A tendency among pediatricians in Greece to use higher-than-recommended
doses of clarithromycin was noted over several years, prompting this
study of the safety and tolerability of this macrolide in 343 children
over a period of 9 months. The study group comprised nonhospitalized
patients of 29 pediatricians practicing in Athens. All were prescribed
clarithromycin for upper respiratory (n = 257) or lower respiratory
tract infection (n = 78). Overall, 77.8% were treated with doses that
exceeded the recommended dose of 15 mg/kg/day, and 26% received doses
of >= 30 mg/kg/day (median dose, 20 mg/kg/day). The tolerability of
clarithromycin was judged as “very good” in 75% of the children, as
“good” in 16%, and as “moderate” in 5%, whereas intolerability
was observed in 4% of the cases. Adverse reactions, mainly
gastrointestinal in nature, were reported in 17.5% of the cases. With
regard to both tolerability and adverse events recorded, there were no
statistically significant differences between the group of patients who
received the recommended dose and the group who received higher doses.
Clarithromycin continues to present a safe and well-tolerated profile
for the treatment of common pediatric infections, even when administered
at higher-than-recommended doses. Whether it is more efficacious in this
setting is a matter for further study.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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