Peptide YY (3-36) represents a high percentage of total PYY immunoreactivity in preterm and full-term infants and correlates independently with markers of adiposity and serum ghrelin concentrations
δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Peptide YY (3-36) represents a high percentage of total PYY
immunoreactivity in preterm and full-term infants and correlates
independently with markers of adiposity and serum ghrelin concentrations
Siahanidou, Tania
Mandyla, Helen
Militsi, Helen and
Papassotiriou, Ioannis
Chrousos, George
The gut hormone peptide YY 3-36 [PYY (3-36)] has been suggested to
posses anorexigenic actions in animals and human adults. However, its
circulating concentrations and function have not been studied in
neonates. Serum concentrations of PYY (3-36) were determined by RIA
(RIA) in 62 healthy preterm infants [mean(SD) gestational age,
32.0(2.1) weeks; postnatal age, 40.9(14.8 d)] and 15 healthy fullterm
infants of comparable postnatal age and gender. The correlations between
PYY (3-36) levels and anthropometric characteristics, food intake,
growth rates and circulating concentrations of total PYY, ghrelin,
leptin, insulin and adiponectin were examined. Mean (SD) PYY (3-36)
concentrations were higher in preterm [543.7(157.6) ng/L] than full
term infants [350.9(114.1) ng/L; p < 0.001] and accounted for 48% and
42% of total PYY basal plasma immunoreactivity in preterm and full term
infants, respectively. In multiple regression analysis, PYY (3-36)
concentrations correlated negatively with the infants’ BMI and
positively with serum ghrelin concentrations, but not with caloric
intake, weight gain or concentrations of any other hormone studied. In
conclusion, PYY (3-36) represents almost half of total PYY
immunoreactivity in neonates. It’s correlations with ghrelin and BMI
suggest a role of this peptide in the regulation of energy homeostasis;
however, its specific functions and physiologic significance in neonates
remain to be elucidated.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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