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86. Increased levels of plasminogen activator inhibitor-1 in diabetic hypertensive patients

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86. Increased levels of plasminogen activator inhibitor-1 in diabetic hypertensive patients
Karpanou, E.A. Vyssoulis, G.P. Toutouza, M.G. Skoumas, J.N. Toutouzas, P.K.
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
1996
Increased levels of plasminogen activator inhibitor 1 (PAI-1) have been proposed as an independent risk factor for coronary artery disease and myocardial infarction. PAI-1 levels have not been reported according to serum lipid values in hypertensive patients with diabetes mellitus. To this end, 2039 patients with essential hypertension were studied according to serum glucose levels, <100 mg/dl (n=1110), 100-115 mg/dl (n=568) and >115 mg/dl (n=361). PAI-1 levels increased in parallel to serum glucose levels (2.6, 3.1, 3.6 Ul/ml, p<0.0001). Patients with increased PAI-1 values (>3.5 Ul/ml, n=641) had higher serum glucose (107 vs 99 mg/dl, p<0.0001) and triglycérides (131 vs 115 mg/dl) with lower HDL values (47 vs 49 mg/dl, p<0.001) and similar total and LDL cholesterol and total fibrinogen (p=NS). Furthermore, patients with high triglycérides (>150 mg/dl, n=463) had higher PAI-1 levels (3.3 vs 2.8 Ul/ml, p<0.001). It is concluded that PAI-1 values are increased in hypertensive patients with hyperglycemia, glucose tolerance or diabetes mellitus, in combination with high triglycérides, thus adding another risk factor in these high risk patients. © Pearson Professional Ltd 1996. (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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